Journal Title: Autumn 2009
Article title: Comparison of maternal serum Tumor Necrosis Factor-alpha (TNF-α) in severe and mild preeclampsia versus normal pregnancy

Article PDF File:
Page From: 153 To: 158      
Article abstract:
Background: Preeclampsia is a disorder unique to pregnancy and has long been recognized as an important contributor of maternal and fetal morbidity and mortality. It is suggested that cytokines such as Tumor Necrosis Factor-alpha (TNF-α) have an important role in the pathogenesis of preeclampsia and may cause generalized endothelial dysfunction. Objective: The aim of this study was comparison of maternal serum TNF-α in severe and mild preeclampsia versus normal pregnancy. Materials and Methods: This study was performed on 37 women with preeclampsia (17 mild and 20 severe preeclampsia) and 41 normotensive pregnant women with similar gestational age at third trimester of pregnancy. All the preeclamptic cases had blood pressure ≥ 140/90 mmHg and proteinuria ≥ 300 mg in a 24-h urine sample. Maternal serum TNF-α concentration was compared in all of them. Results: The level of TNF-α concentration was not statistically different between the studied groups. No significant correlation was found between preeclampsia and control group as they were compared in the view of maternal serum TNF-α concentration. Conclusion: These findings suggest that serum TNF-α is not significantly associated with preeclampsia.
Article KeyWords:
Tumor Necrosis Factor-alpha (TNF-α) Preeclampsia Normal pregnancy.
Article Authors:

	Fatemeh Vahid Roudsari	First Author
	Hossein Ayatollahi	Other Author
	Habibollah Esmaeily	Other Author
	Maliheh Hasanzadeh	Other Author
	Masoud Shahabian	Other Author
	Leila Pour Ali	Other Author
	Sedigheh Ayati	Corresponding Author	ayatis@mums.ac.ir