En 1680-6433 2008-2177 Background: Lectins the multivalent carbohydrate binding proteins are also employed to ascertain differentiation and characterization of the specific cell surface carbohydrate ligands/ receptors of different cell types including spermatozoa and posses novel biomedical importance. Objective: SF50 the sialic acid specific lectin was employed on goat cauda epididymal spermatozoa to investigate its effect(s) on the physiology of sperm cells if any. Materials and Methods: A protein factor SF50 was obtained from spermatheca/ ovotestis gland of marine snail Telescopium telescopium by precipitation with 50% ammonium sulfate. Different concentrations of SF50 and Bovine serum albumin (BSA) as control were added with washed goat cauda epididymal spermatozoa and observed immediately and after 20 s and 60 s of incubation. Results: SF50 treated sperm cells exhibited head-to-head type agglutination. The degree of agglutination varied (p Agglutination Lectin Snail Sperm. 10 17 Samata Maji No Uttam Datta No Manik Lal Hembram No